Normal Reference Ranges
Adult
Negative Qualitative
Pediatric
Negative Qualitative
Clinical Significance
Strongly associated with seronegative spondyloarthropathies, especially Ankylosing Spondylitis (approx. 90% positive), Reiter's syndrome, and psoriatic arthritis.
Causes of High
- Presence of HLA-B27 allele
Causes of Low
- Absence of HLA-B27 allele (Normal)