Normal Reference Ranges
Adult
70 - 400 mg/dL
Pediatric
Varies significantly by age mg/dL
Clinical Significance
Predominant immunoglobulin in mucosal secretions. Selective IgA deficiency is the most common primary immunodeficiency and puts patients at risk for anaphylaxis during blood transfusions.
Causes of High
- Chronic infections
- Liver disease / cirrhosis
- IgA myeloma
- Inflammatory bowel disease
Causes of Low
- Selective IgA deficiency
- Common variable immunodeficiency (CVID)
- Immunosuppressive therapy