Normal Reference Ranges
Adult
0 - 100 kU/L
Pediatric
Varies by age kU/L
Clinical Significance
Mediates type I hypersensitivity reactions and immune response to parasites. Elevated levels correlate strongly with allergic predisposition and ABPA.
Causes of High
- Atopic dermatitis
- Asthma
- Allergic rhinitis
- Parasitic infections (helminths)
- Allergic bronchopulmonary aspergillosis (ABPA)
- Hyper-IgE syndrome (Job syndrome)
Causes of Low
- Hypogammaglobulinemia
- Normal finding