Normal Reference Ranges
Adult
80 - 100 fL
Pediatric
75 - 90 (lower in children) fL
Clinical Significance
Measures the average size of red blood cells. The most critical index for classifying the etiology of anemia (microcytic, normocytic, or macrocytic).
Causes of High
- Macrocytic anemia (B12/Folate deficiency)
- Liver disease
- Alcoholism
- Myelodysplastic syndromes
- Hypothyroidism
Causes of Low
- Microcytic anemia (Iron deficiency)
- Thalassemia
- Anemia of chronic disease
- Lead poisoning