Normal Reference Ranges
Adult
0.08 - 0.56 µmol/L
Pediatric
N/A µmol/L
Clinical Significance
Highly sensitive marker to distinguish between Vitamin B12 and Folate deficiency. MMA is elevated in B12 deficiency but normal in folate deficiency.
Causes of High
- Vitamin B12 (Cobalamin) deficiency
- Methylmalonic aciduria (genetic defect)
- Renal insufficiency
Causes of Low
- Normal finding