Normal Reference Ranges
Adult
0.5 - 4.0 ng/mL/hr
Pediatric
Varies heavily by age ng/mL/hr
Clinical Significance
Enzyme secreted by the juxtaglomerular apparatus. The Aldosterone-to-Renin Ratio (ARR) > 20 is the screening test of choice for Primary Hyperaldosteronism.
Causes of High
- Secondary hyperaldosteronism (Renal artery stenosis)
- Dehydration
- Addison's disease
- Diuretic therapy
Causes of Low
- Primary hyperaldosteronism (Conn's syndrome)
- High sodium intake