Normal Reference Ranges
Adult
Negative Qualitative
Pediatric
Negative Qualitative
Clinical Significance
Treponemal-specific test. Remains positive for life after infection. Standard screening algorithm utilizes a reverse sequence starting with automated IgG/IgM.
Causes of High
- Treponema pallidum infection (Syphilis)
- Successful past treated syphilis infection
Causes of Low
- No exposure to syphilis