Normal Reference Ranges
Adult
50 - 100 mcg/mL
Pediatric
50 - 100 mcg/mL
Clinical Significance
Monitors antiepileptic/mood stabilizer therapy. Toxicity can cause CNS depression, hyperammonemia, hepatotoxicity, and thrombocytopenia.
Causes of High
- Valproic acid toxicity
- Overdose
Causes of Low
- Subtherapeutic dosing
- Non-compliance