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HepB

Protein Subunit

Hepatitis B

Manufacturer

GSK (Engerix-B), Merck (Recombivax HB)

Administration

Intramuscular (IM)

Site: Anterolateral thigh (neonates), Deltoid (adults)

Storage

Refrigerate at 2°C to 8°C. Do not freeze.

Schedule

3 doses

Indications

  • Universal infant vaccination
  • Healthcare workers
  • Travelers to endemic areas
  • Patients on dialysis

Target Ages:

Birth1-2 months6-18 months

Contraindications & Precautions

Contraindications

  • Severe allergic reaction to yeast

Precautions

  • Premature infants weighing < 2000g (delay first dose if mother is HBsAg negative).

Side Effects

Common (Expected)

Injection site sorenessFatigueLow-grade fever

Rare Adverse Events

  • Anaphylaxis

Clinical Information

Effectiveness

Provides >90% protection in healthy adults and >95% in infants.

Patient Counseling

  • Crucial for preventing chronic liver disease and liver cancer.
  • Complete the full 3-dose series for long-lasting protection.