Dosing & Administration
Adult Dose
15-20 mg/kg IV every 8-12 hours (trough-based dosing). 125 mg PO QID for C. diff.
Pediatric Dose
15 mg/kg IV every 6 hours.
Renal Adjustment
Highly renally cleared. Dose strictly based on CrCl and trough levels.
Hepatic Adjustment
No adjustment necessary.
Safety & Special Populations
Pregnancy Category
C - Use only if clearly needed.
Lactation Safety
Compatible (poorly absorbed orally).
Contraindications & Adverse Effects
Contraindications
- Hypersensitivity
Common Adverse Effects
- Red man syndrome (if infused too fast)
- Nephrotoxicity
- Ototoxicity