Medical Guidelines
Curated summaries of the latest clinical practice guidelines.
AHA/ACC/HFSA Heart Failure Guidelines
American Heart Association (AHA) / ACC
Comprehensive guidelines for the management of Heart Failure. Notably elevates SGLT2 inhibitors to Class 1 recommendation for HFrEF.
Management of Acute Coronary Syndromes (ACS)
European Society of Cardiology (ESC)
Integrates NSTE-ACS and STEMI into a single comprehensive ACS guideline. Emphasizes early invasive strategies and potent P2Y12 inhibitors.
Management of Blood Cholesterol
ACC / AHA
Focuses on risk assessment and statin intensity. Recommends non-statin therapies (ezetimibe, PCSK9 inhibitors) for patients with ASCVD at very high risk.
Management of Patients with Atrial Fibrillation
ACC / AHA / ACCP / HRS
Updated guidance on stroke risk stratification (recommends CHA2DS2-VASc), rhythm vs. rate control, and expanding roles for catheter ablation.
Global Strategy for Asthma Management and Prevention
Global Initiative for Asthma (GINA)
Recommends ICS-formoterol as the preferred reliever over SABA alone across all treatment tracks to reduce the risk of severe exacerbations.
Global Strategy for the Diagnosis, Management, and Prevention of COPD
GOLD
Updates the ABCD assessment tool to ABE (E for Exacerbations). Strongly advocates for dual bronchodilator therapy (LAMA/LABA) as initial treatment for many.
Community-Acquired Pneumonia (CAP) Guidelines
Infectious Diseases Society of America (IDSA) / ATS
Diagnosis and treatment of CAP in adults. Emphasizes abandoning routine use of healthcare-associated pneumonia (HCAP) categorization.
Clinical Practice Guidelines for Clostridioides difficile Infection
Infectious Diseases Society of America (IDSA) / SHEA
Recommends fidaxomicin as the preferred initial therapy for C. diff infection over vancomycin. Discusses the role of bezlotoxumab.
Uncomplicated Acute Bacterial Cystitis and Acute Pyelonephritis in Women
Infectious Diseases Society of America (IDSA)
Recommends nitrofurantoin, TMP-SMX, or fosfomycin as first-line for uncomplicated cystitis. Avoid fluoroquinolones for uncomplicated UTI.
Sexually Transmitted Infections Treatment Guidelines
Centers for Disease Control and Prevention (CDC)
Updates on the treatment of Gonorrhea (now recommends a single 500mg IM dose of ceftriaxone) and Chlamydia (doxycycline 100mg BID for 7 days).
Evaluation and Management of Chronic Kidney Disease
KDIGO
Major update highlighting SGLT2 inhibitors and non-steroidal mineralocorticoid receptor antagonists (nsMRAs like finerenone) in both diabetic and non-diabetic CKD.
Clinical Practice Guideline for Acute Kidney Injury
KDIGO
Defines AKI based on serum creatinine rise and urine output criteria. Emphasizes early volume optimization and avoidance of nephrotoxins.
Standards of Care in Diabetes
American Diabetes Association (ADA)
Recommends dual GIP/GLP-1 receptor agonists (tirzepatide) for weight management and glycemic control. Continues to prioritize SGLT2i and GLP-1 RA for CVD risk.
Comprehensive Clinical Practice Guidelines for Medical Care of Patients with Obesity
American Association of Clinical Endocrinology (AACE)
Focuses on a complication-centric approach to obesity management, grading interventions based on the severity of obesity-related comorbidities.
Diagnosis and Management of Gastroesophageal Reflux Disease
American College of Gastroenterology (ACG)
Provides an evidence-based approach to PPI trials, pH impedance testing, and the management of extraesophageal GERD symptoms.
Management of Crohn's Disease in Adults
American College of Gastroenterology (ACG)
Guidelines on the use of biologics (anti-TNF, ustekinumab, vedolizumab) and immunomodulators for induction and maintenance of remission.
Diagnosis and Management of Portal Hypertension and Variceal Bleeding
AASLD
Updates the Baveno criteria for primary and secondary prophylaxis of variceal bleeding. Emphasizes non-selective beta-blockers (NSBBs) and EVL.
Early Management of Patients With Acute Ischemic Stroke
AHA / ASA
Guidelines on IV alteplase administration (up to 4.5 hours) and mechanical thrombectomy (up to 24 hours in select patients based on perfusion imaging).
Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults
American Academy of Neurology (AAN)
Recommends divalproex, topiramate, and beta-blockers (metoprolol, propranolol, timolol) for migraine prophylaxis. Later updates include CGRP inhibitors.
Adult Advanced Cardiovascular Life Support (ACLS)
American Heart Association (AHA)
Focuses on early epinephrine administration for non-shockable rhythms, high-quality CPR, targeted temperature management (TTM), and debriefing.
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock
Surviving Sepsis Campaign (SSC)
Recommends administering 30 mL/kg of IV crystalloid fluid within the first 3 hours. Suggests balanced crystalloids over normal saline.
Diagnosis and Management of the Initial UTI in Febrile Infants and Children
American Academy of Pediatrics (AAP)
Provides algorithms for urine catheterization vs. bag specimens and indications for Renal Bladder Ultrasound (RBUS) and VCUG.
Clinical Practice Guideline: Management of Asthma Exacerbations in Children
American Academy of Pediatrics (AAP)
Guidance on the use of systemic corticosteroids, inhaled bronchodilators, and magnesium sulfate for severe pediatric asthma exacerbations.
Adjuvant Endocrine Therapy for Women With Hormone Receptor-Positive Breast Cancer
American Society of Clinical Oncology (ASCO)
Updates the duration of adjuvant endocrine therapy (tamoxifen or aromatase inhibitors) to up to 10 years for patients with higher risk of recurrence.
Non-Small Cell Lung Cancer
National Comprehensive Cancer Network (NCCN)
Comprehensive algorithms for molecular testing (EGFR, ALK, ROS1, PD-L1) and selection of targeted therapies and immunotherapies in NSCLC.
Safe Prevention of the Primary Cesarean Delivery
ACOG / SMFM
Defines arrest of labor more strictly (e.g., 6 cm dilation for active phase) to safely reduce the primary cesarean delivery rate.
WHO Guidelines for Safe Surgery
World Health Organization (WHO)
Introduced the surgical safety checklist (Sign-in, Time-out, Sign-out) which drastically reduces perioperative morbidity and mortality globally.
Guideline for the Treatment of Rheumatoid Arthritis
American College of Rheumatology (ACR)
Recommends methotrexate as the first-line therapy for most patients with RA. Discusses the role of tapering bDMARDs or tsDMARDs in sustained remission.
Guideline for the Management of Gout
American College of Rheumatology (ACR)
Strongly recommends initiating urate-lowering therapy (ULT), preferentially allopurinol, in patients with frequent gout flares or tophi. Treat-to-target strategy of serum urate <6 mg/dL.
Management of Venous Thromboembolism
American Society of Hematology (ASH)
Comprehensive recommendations for the diagnosis and treatment of DVT and PE, including the preference for DOACs over VKAs for most patients without cancer.
Guidelines for Sickle Cell Disease
American Society of Hematology (ASH)
Provides extensive guidance on stem cell transplantation, management of acute and chronic pain, and prevention of cardiopulmonary and kidney disease in SCD.
Practice Guideline for the Treatment of Patients With Major Depressive Disorder
American Psychiatric Association (APA)
Standard framework for MDD management including SSRIs/SNRIs, psychotherapy (CBT), and ECT for severe, treatment-resistant, or psychotic depression.
Practice Guideline for the Treatment of Patients With Schizophrenia
American Psychiatric Association (APA)
Recommends clozapine for treatment-resistant schizophrenia and emphasizes the use of long-acting injectable (LAI) antipsychotics for non-adherence.
Management of Benign Prostatic Hyperplasia (BPH)
American Urological Association (AUA)
Evaluates medical therapies (alpha-blockers, 5-ARIs, PDE5 inhibitors) and highlights minimally invasive surgical therapies (MIST) like UroLift and Rezum.
Surgical Management of Stones: AUA/Endourology Society Guideline
AUA / Endourology Society
Guidance on SWL, URS, and PCNL based on stone size and location. Recommends medical expulsive therapy (MET) using alpha-blockers for uncomplicated distal ureteral stones.
Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics
American Academy of Dermatology (AAD)
Provides detailed recommendations on the use of TNF-alpha inhibitors, IL-17 inhibitors, and IL-23 inhibitors for moderate-to-severe plaque psoriasis.
Guidelines of care for the management of acne vulgaris
American Academy of Dermatology (AAD)
Recommends topical retinoids as foundational therapy. Strongly advises limiting the use of systemic antibiotics to reduce resistance, preferring isotretinoin for severe nodular acne.
National Guidelines for Extra-Pulmonary Tuberculosis
Indian Council of Medical Research (ICMR) / NTEP
Updated diagnostic algorithms emphasizing the use of Xpert MTB/RIF and TrueNat as upfront diagnostics for diverse forms of extra-pulmonary TB in India.
API Recommendations for the Management of Type 2 Diabetes in Indians
Association of Physicians of India (API)
Tailored guidelines for the Asian Indian phenotype, which has higher visceral adiposity. Emphasizes early initiation of combination therapy and specific dietary modifications for the Indian context.
ICMR Treatment Guidelines for Antimicrobial Use in Common Syndromes
Indian Council of Medical Research (ICMR)
Crucial guidelines to combat India's high AMR burden. Recommends against empiric broad-spectrum antibiotics for mild community-acquired infections and provides local antibiogram-based protocols.
Good Clinical Practice Recommendations for PCOS in India
Federation of Obstetric and Gynaecological Societies of India (FOGSI)
Comprehensive approach to PCOS management in the Indian population, focusing on lifestyle modification (diet and yoga), combined oral contraceptives, and insulin sensitizers.
Cardiological Society of India (CSI) Guidelines for Hypertension
Cardiological Society of India (CSI)
Defines hypertension thresholds for the Indian population and recommends early use of low-dose combination therapy (e.g., ARB + CCB) due to high salt intake profiles in India.
National Snakebite Management Protocol
Ministry of Health and Family Welfare (MoHFW) / ICMR
Updated protocols for the diagnosis and management of snakebites (the 'Big Four' venomous snakes in India), detailing indications and optimal dosing for polyvalent Anti-Snake Venom (ASV).